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Consequently, the methods from previous section performing a univariate (or bivariate) meta-analysis need to be extended to perform a (multivariate) meta-analysis where the factor-outcome associations (and intercept) are adjusted for additional factors. For the two-stage method, multivariable logistic regression models are estimated in each study: (Model. 2 ) which yields an intercept, a risk factor-outcome association, confounder-outcome associations and a within-study covariance matrix for each study.

The fully random-effects one-stage model with multiple risk factors is specified as follows: (ModelC).